Basic Aspects of Catechol-O-Methyltransferase and the Clinical Applications of Its Inhibitors by Nissinen

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Author
Nissinen
Publisher
Academic Press
Date of release
Pages
336
ISBN
9780123813268
Binding
Hardcover
Illustrations
Format
PDF, EPUB, MOBI, TXT, DOC
Rating
5
38

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Book review

Volume 95 of International Review of Neurobiology focuses on Catechol-O-methyltransferase inhibition, and its clinical application in relation to Parkinson’s disease. Chapters cover COMT gene and proteins, L-dopa treatment in Parkinson’s disease, the latest research on COMT inhibitors and their clinical applications, as well as future prospects for their use.

  • Up-to-date summary of biochemistry and pharmacology of COMT and its inhibitors
  • Preclinical models in COMT inhibitor devlopment
  • Transgenic COMT mice – latest information summarized
  • Chemistry of COMT inhibitors and their design with molecular modelling
  • COMT gene and its regulation and relation to dopamine related diseases
  • Role of cofactor SAM regulation in relation to homocysteine
  • Nonclinical and clinical safety of COMT inhibitors summarized
  • Future prospects of COMT inhibitors in Parkinson’s disease


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